Staphylococcus aureus and Influenza A Virus: Partners in Coinfection.
Identifieur interne : 000B51 ( Main/Exploration ); précédent : 000B50; suivant : 000B52Staphylococcus aureus and Influenza A Virus: Partners in Coinfection.
Auteurs : Michelle E. Mulcahy [Irlande (pays)] ; Rachel M. Mcloughlin [Irlande (pays)]Source :
- mBio [ 2150-7511 ] ; 2016.
Descripteurs français
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- MESH :
English descriptors
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- MESH :
Abstract
Nasal carriage of Staphylococcus aureus is a significant risk factor for secondary staphylococcal pneumonia in influenza A virus (IAV)-infected hosts. However, little research has been undertaken to define the environmental and physiological changes that cause S. aureus to shift from commensal to pathogenic organism in this setting. The ability of virus-driven danger signals to cause S. aureus to transition from commensalism to pulmonary infection was explored in a recent study by Reddinger et al. R. M. Reddinger, N. R. Luke-Marshall, A. P. Hakansson, and A. A. Campagnari, mBio 7(6):e01235-16, 2016, http://dx.doi.org/10.1128/mBio.01235-16 The authors report that physiological host changes, including febrile temperature and a combination of host stress response signals, caused S. aureus biofilms to disperse from the nasal environment and cause active pulmonary infection. This commentary discusses the new finding in light of the current understanding of the mechanisms behind staphylococcal coinfection with IAV. In addition, it considers the mechanisms behind staphylococcal dispersal in this model. Overall, the study indicates that interkingdom signaling may occur following IAV infection and this likely contributes to sensitizing the IAV-infected host to secondary staphylococcal pneumonia.
DOI: 10.1128/mBio.02068-16
PubMed: 27965455
Affiliations:
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Mcloughlin</name><affiliation wicri:level="1"><nlm:affiliation>Host-Pathogen Interactions Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland rachel.mcloughlin@tcd.ie.</nlm:affiliation><country wicri:rule="url">Irlande (pays)</country><wicri:regionArea>Host-Pathogen Interactions Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin</wicri:regionArea><wicri:noRegion>Dublin</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27965455</idno><idno type="pmid">27965455</idno><idno type="doi">10.1128/mBio.02068-16</idno><idno type="wicri:Area/PubMed/Corpus">000331</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000331</idno><idno type="wicri:Area/PubMed/Curation">000330</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000330</idno><idno type="wicri:Area/PubMed/Checkpoint">000345</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000345</idno><idno type="wicri:Area/Ncbi/Merge">000834</idno><idno type="wicri:Area/Ncbi/Curation">000834</idno><idno type="wicri:Area/Ncbi/Checkpoint">000834</idno><idno type="wicri:Area/Main/Merge">000B51</idno><idno type="wicri:Area/Main/Curation">000B51</idno><idno type="wicri:Area/Main/Exploration">000B51</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Staphylococcus aureus and Influenza A Virus: Partners in Coinfection.</title><author><name sortKey="Mulcahy, Michelle E" sort="Mulcahy, Michelle E" uniqKey="Mulcahy M" first="Michelle E" last="Mulcahy">Michelle E. Mulcahy</name><affiliation wicri:level="1"><nlm:affiliation>Host-Pathogen Interactions Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.</nlm:affiliation><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Host-Pathogen Interactions Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin</wicri:regionArea><wicri:noRegion>Dublin</wicri:noRegion></affiliation></author><author><name sortKey="Mcloughlin, Rachel M" sort="Mcloughlin, Rachel M" uniqKey="Mcloughlin R" first="Rachel M" last="Mcloughlin">Rachel M. Mcloughlin</name><affiliation wicri:level="1"><nlm:affiliation>Host-Pathogen Interactions Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland rachel.mcloughlin@tcd.ie.</nlm:affiliation><country wicri:rule="url">Irlande (pays)</country><wicri:regionArea>Host-Pathogen Interactions Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin</wicri:regionArea><wicri:noRegion>Dublin</wicri:noRegion></affiliation></author></analytic><series><title level="j">mBio</title><idno type="eISSN">2150-7511</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Coinfection</term><term>Humans</term><term>Influenza A virus</term><term>Orthomyxoviridae Infections</term><term>Pneumonia, Staphylococcal</term><term>Staphylococcal Infections</term><term>Staphylococcus aureus</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Co-infection</term><term>Humains</term><term>Infections à Orthomyxoviridae</term><term>Infections à staphylocoques</term><term>Pneumopathie à staphylocoques</term><term>Staphylococcus aureus</term><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Coinfection</term><term>Humans</term><term>Influenza A virus</term><term>Orthomyxoviridae Infections</term><term>Pneumonia, Staphylococcal</term><term>Staphylococcal Infections</term><term>Staphylococcus aureus</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Co-infection</term><term>Humains</term><term>Infections à Orthomyxoviridae</term><term>Infections à staphylocoques</term><term>Pneumopathie à staphylocoques</term><term>Staphylococcus aureus</term><term>Virus de la grippe A</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Nasal carriage of Staphylococcus aureus is a significant risk factor for secondary staphylococcal pneumonia in influenza A virus (IAV)-infected hosts. However, little research has been undertaken to define the environmental and physiological changes that cause S. aureus to shift from commensal to pathogenic organism in this setting. The ability of virus-driven danger signals to cause S. aureus to transition from commensalism to pulmonary infection was explored in a recent study by Reddinger et al. R. M. Reddinger, N. R. Luke-Marshall, A. P. Hakansson, and A. A. Campagnari, mBio 7(6):e01235-16, 2016, http://dx.doi.org/10.1128/mBio.01235-16 The authors report that physiological host changes, including febrile temperature and a combination of host stress response signals, caused S. aureus biofilms to disperse from the nasal environment and cause active pulmonary infection. This commentary discusses the new finding in light of the current understanding of the mechanisms behind staphylococcal coinfection with IAV. In addition, it considers the mechanisms behind staphylococcal dispersal in this model. Overall, the study indicates that interkingdom signaling may occur following IAV infection and this likely contributes to sensitizing the IAV-infected host to secondary staphylococcal pneumonia.</div></front></TEI><affiliations><list><country><li>Irlande (pays)</li></country></list><tree><country name="Irlande (pays)"><noRegion><name sortKey="Mulcahy, Michelle E" sort="Mulcahy, Michelle E" uniqKey="Mulcahy M" first="Michelle E" last="Mulcahy">Michelle E. Mulcahy</name></noRegion><name sortKey="Mcloughlin, Rachel M" sort="Mcloughlin, Rachel M" uniqKey="Mcloughlin R" first="Rachel M" last="Mcloughlin">Rachel M. Mcloughlin</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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